Navegando por Autor "Ferreira, Carolina Cruz"

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    Improvement of Titanium Corrosion Resistance by Coating with Poly-Caprolactone and Poly-Caprolactone/Titanium Dioxide: Potential Application in Heart Valves
    (2017) Ferreira, Carolina Cruz; Ricci, Virgilio Pereira; Sousa, Lucíola Lucena de; Mariano, Neide Aparecida; Campos, Maria Gabriela Nogueira
    Heart diseases affect part of world population and generally involves the functioning of valves. Valves replacement is the most common treatment and the choice between synthetic or natural/biological implants depends on several factors. Synthetic implants have greater durability, whereas biological ones are more biocompatible. This work proposes the use of polymeric coating on titanium metal surface to increase implant biocompatibility. Poly-caprolactone (PCL) has demonstrated greater efficacy for biomedical applications due to its biocompatibility. It can easily form films and coat surfaces. Titanium discs were submitted to alkaline and thermal treatments and coated with 1%PCL and 1%PCL+TiO2. For both conditions, PCL crystals were found in titanium coated surface (SEM and EDX) and X-ray diffractogram confirmed PCL coating. Infrared Spectroscopy spectra showed both PCL and TiO2 characteristic peaks. Moreover, corrosion resistance of coated disc has considerably increased, proving the effectiveness of PCL as coating material and its potential application in cardiac valves.
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    Titanium Biomimetically Coated With Hydroxyapatite, Silver Nitrate and Polycaprolactone, for Use In Biomaterials (Biomedicine)
    (2019) Ferreira, Carolina Cruz; Sousa, Lucíola Lucena de; Ricci, Virgilio Pereira; Rigo, Eliana Cristina da Silva; Ramos, Alfeu Saraiva; Campos, Maria Gabriela Nogueira; Mariano, Neide Aparecida
    Titanium is used in orthopedic and orthodontic implants because it has good corrosion resistance and excellent biocompatibility. Thus, studies seek to obtain a coating to improve the adhesion between the bone and the implant, by modifying the metal’s surface. The objective of this work was to biomimetically coat C.P. Ti with hydroxyapatite doped with silver nitrate, a component with antimicrobial properties, coating the metallic-ceramic composite with a polycaprolactone polymer film, which is known by generate improved implant-tissue interaction, and reducing postoperative complications from bacterial infections. The characterization of the material demonstrated the existence of the coating overall surface of the metallic substrate. The results obtained from the bacterial culture tests with Staphylococcus aureus showed that nitrate was effective in reducing the amount of live bacteria present in the supernatant, as well as those adhered to the surface of the material. In addition, the polymeric coating did not prevent the release of the bactericidal agent, not interfering in the effect there.