Characterization and immunomodulatory effects of glucans from Pleurotus albidus, a promising species of mushroom for farming and biomass production

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dc.contributor.authorCastro-Alves, Victor Costa
dc.contributor.authorGomes, Daniel
dc.contributor.authorMenolli, Nelson
dc.contributor.authorSforça, Maurício Luís
dc.contributor.authorNascimento, João Roberto Oliveira do
dc.date.accessioned2024-09-16T13:42:07Z
dc.date.available2024-09-16T13:42:07Z
dc.date.issued2017-02
dc.description.abstractPolysaccharides from a number of mushroom species are recognized as functional food ingredients with potential health benefits, including immunomodulatory effects. In this study, polysaccharides extracted from the basidiome with cold water (BaCW), hot water (BaHW), and hot alkali (BaHA) solution, and exo- (MyEX) and endopolysaccharides (MyEN) from the submerged culture of Pleurotus albidus, a promising species for farming and biomass production, were analyzed for their chemical composition and structure and immunomodulatory effects on macrophages. Compositional (HPAEC-PAD and HPSEC-RID/MWD) and structural (FT-IR, 1D- and 2D-NMR) analyses identified BaCW and MyEX as β-(1,6)-branched β-(1,3)-glucans, BaHW and MyEN as α-(1,3)-(1,2)-branched α-(1,6)-glucans, and BaHA as a mixture of α-(1,6)- and β-(1,3)-glucans. BaCW and MyEX stimulated the production of tumor necrosis factor alpha (TNF-α) and nitric oxide (NO), but not interleukin-6 (IL-6), and decreased phagocytosis of zymosan particles. In contrast, BaHW and MyEN induced TNF-α, NO and IL-6 production, and increased zymosan phagocytosis, while BaHA displayed intermediary effects in comparison the other polysaccharides. In conclusion, the basidiome and the submerged culture of P. albidus are sources of easily extractable α- and β-glucans with potential immunomodulatory effects.
dc.identifier.doi10.1016/j.ijbiomac.2016.11.059
dc.identifier.issn0141-8130
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/2609
dc.publisherElsevier BV
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.subject.keywordsPolysaccharides
dc.subject.keywordsimmunomodulatory effects
dc.titleCharacterization and immunomodulatory effects of glucans from Pleurotus albidus, a promising species of mushroom for farming and biomass production
dc.typeArtigos
oaire.citation.volume95

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