Preparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release

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dc.contributor.authorBrianezi, Samira Faleiros Silva
dc.contributor.authorCastro, Karine Cappuccio
dc.contributor.authorPiazza, Rodolfo Debone
dc.contributor.authorMelo, Maria do Socorro Fernandes
dc.contributor.authorPereira, Rafael Matsumoto
dc.contributor.authorMarques, Rodrigo Fernando Costa
dc.contributor.authorCampos, Maria Gabriela Nogueira
dc.date.accessioned2024-05-14T15:40:54Z
dc.date.available2024-05-14T15:40:54Z
dc.date.issued2018
dc.description.abstractIn this paper, a novel wound dressing membrane for controlled release of gentamicin (GE), while covering and protecting the wound was investigated. Chitosan (CHI) was associated with methoxy polyethylene glycol - polycaprolactone copolymer (mPEG-PCL) to prepare the blended wound dressing membranes. The use of copolymer mPEG-PCL was necessary to improve the compatibility between CHI and PCL. The association of CHI and PCL was required to control the water retention and release rate of encapsulated GE. In vitro release studies were performed with the mPEG-PCL/CHI-GE membranes in order to evaluate the effect of copolymer concentration on the kinetics of GE release and water uptake. Reduced burst release rates and swelling ratios were observed for the 1/2 and 1/4 mPEG-PCL/CHI-GE membranes. In addition, all gentamicin-loaded membranes inhibited S. aureus and E. coli growth, and demonstrated color, moisture and thermal stability. Therefore, mPEG-PCL/CHI-GE membranes showed important features for potential wound dressing and drug delivery applications.
dc.identifier.doi10.1590/1980-5373-mr-2017-0951
dc.identifier.issn1516-1439
dc.identifier.otherS1516-14392018000600207-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/913
dc.relation.ispartofMaterials Research
dc.subjectCopolymer
dc.subjectblend
dc.subjectmethoxy polyethylene glycol
dc.subjectpolycaprolactone
dc.subjectantibiotic
dc.subjectdrug delivery
dc.titlePreparation and Characterization of Chitosan/mPEG-PCL Blended Membranes for Wound Dressing and Controlled Gentamicin Release
dc.typeArtigos
oaire.citation.issue6
oaire.citation.volume21

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