Asymptomatic Leishmania infection in blood donors from a major blood bank in Northeastern Brazil: a cross-sectional study

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dc.contributor.authorSilva, Lucas Portela
dc.contributor.authorMontenegro, Silvia
dc.contributor.authorWerkauser, Roberto
dc.contributor.authorSales, Kamila Gaudêncio da Silva
dc.contributor.authorSoares, Fábia Carla Silva
dc.contributor.authorCosta, Vlaudia Maria Assis
dc.contributor.authorBezerra, Ana Cristina
dc.contributor.authorPinto, Maria Betania do Amaral
dc.contributor.authorFerreira, Suzany Maria
dc.contributor.authorNeitzke-Abreu, Herintha Coeto
dc.contributor.authorDantas-Torres, Filipe
dc.contributor.authorLima Junior, Manoel Sebastião da Costa
dc.date.accessioned2024-05-16T10:25:35Z
dc.date.available2024-05-16T10:25:35Z
dc.date.issued2020
dc.description.abstractABSTRACT This study has estimated the risk of Leishmania transmission via blood transfusion in one of the largest blood banks in Northeastern Brazil, where visceral leishmaniasis is endemic. Five hundred blood samples from donors were tested for circulating Leishmania spp. DNA by real-time PCR. Positive samples were tested by a species-specific conventional PCR targeting Leishmania infantum . Overall, 6.2% (95% CI: 4.1–8.3%) of the samples carried Leishmania DNA and in one sample the species was confirmed as L. infantum . No statistically significant differences were found in relation to gender, sex, education level, incomeas well as the place of residence between positive and negative blood donors. Our results confirm the presence of asymptomatic Leishmania carriers among blood donors in a large blood bank in Northeastern Brazil. Considering the studied population, we estimate that for every 1,000 blood donors screened, 41 to 83 will be positive for Leishmania DNA. This finding reinforces the urgent need for elaborating specific Blood bank guidelines to allow the early detection of asymptomatic Leishmania carriers among blood donors before their blood products are transfused to uninfected individuals.
dc.identifier.doi10.1590/s1678-9946202062092
dc.identifier.issn0036-4665
dc.identifier.otherS0036-46652020000100244-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/1538
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.subjectBlood donors
dc.subjectLeishmania
dc.subjectAsymptomatic infection
dc.subjectBlood bank
dc.subjectSurveillance
dc.titleAsymptomatic Leishmania infection in blood donors from a major blood bank in Northeastern Brazil: a cross-sectional study
dc.typeArtigos
oaire.citation.volume62

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