Mutagenic damage among bronchiectasis patients attending in the pulmonology sector of a hospital in southern Brazil

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dc.contributor.authorOlmedo, Daniel Wenceslau Votto
dc.contributor.authorMartins, Katheryne Benini
dc.contributor.authorPaz, Milene Machado
dc.contributor.authorFernandes, Caroline Lopes Feijo
dc.contributor.authorSilva Júnior, Flavio Manoel Rodrigues da
dc.contributor.authorRamos, Daniela Fernandes
dc.date.accessioned2024-05-17T14:06:52Z
dc.date.available2024-05-17T14:06:52Z
dc.date.issued2022
dc.description.abstractSUMMARY OBJECTIVE: Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a disease related to the exacerbation of the inflammatory process and oxidative stress, this study searched to investigate the micronucleus frequency in patients with and without bronchiectasis treated at a specialized pulmonology service in a hospital in the extreme south of Brazil. METHODS: Patients with a confirmed tomographic diagnosis of bronchiectasis were defined as cases. Mutagenicity was evaluated by the micronucleus test in patients’ oral mucosa cells. Data collection was performed through a questionnaire containing socioeconomic, demographic, lifestyle, and health condition information. RESULTS: Of the 95 patients involved in this study, 21 (22.1%) were diagnosed with bronchiectasis aged between 12 and 89 years. There was no significant difference in the frequency of micronucleus between patients with and without bronchiectasis. There was a significant positive association between age and frequency of micronucleus among patients with bronchiectasis, but this association does not occur among patients without the disease. CONCLUSION: This is the first study to investigate data on the prevalence and clinical and epidemiological aspects of this chronic disease in Brazil, especially those related to the genotoxicity outcome.
dc.identifier.doi10.1590/1806-9282.20220178
dc.identifier.issn0104-4230
dc.identifier.otherS0104-42302022000901191-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/1940
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.subjectFibrosis
dc.subjectMutagenesis
dc.subjectBronchiectasis
dc.subjectMorbidity
dc.titleMutagenic damage among bronchiectasis patients attending in the pulmonology sector of a hospital in southern Brazil
dc.typeArtigos
oaire.citation.endPage1198
oaire.citation.issue9
oaire.citation.startPage1191
oaire.citation.volume68

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