Evaluation of cardiac autonomic function and low-grade inflammation in children with obesity living in the Northeast Brazilian region

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dc.contributor.authorCosta, Paulo César Trindade
dc.contributor.authorSouza, Joelma Rodrigues de
dc.contributor.authorLima, Poliana Correia
dc.contributor.authorDuarte, Davyson Barbosa
dc.contributor.authorNeves, Thallyta Alanna Ferreira Viana das
dc.contributor.authorPereira, Joicy Karla Grangeiro
dc.contributor.authorSilva-Luis, Cristiane Cosmo
dc.contributor.authorMoraes, Rúbia Cartaxo Squizato de
dc.contributor.authorBraga, Valdir de Andrade
dc.contributor.authorSouza, Evandro Leite de
dc.contributor.authorMartins, Vinícius José Baccin
dc.contributor.authorAlves, José Luiz de Brito
dc.date.accessioned2024-05-14T12:34:15Z
dc.date.available2024-05-14T12:34:15Z
dc.date.issued2024
dc.description.abstractAbstract Objective Evaluate autonomic function and low-grade inflammation and characterize the correlation between these variables in schoolchildren with obesity living in the Brazilian northeast region. Methods 84 children with obesity and 41 with normal weight were included in this cross-sectional study. Anthropometry, body composition, blood pressure (BP), inflammatory biomarkers, and heart rate variability (HRV) indexes were analyzed in children aged 7 to 11 years. Results children with obesity had increased systolic (p= 0.0017) and diastolic (p= 0.0131) BP and heart rate (p= 0.0022). The children with obesity displayed significantly lower SDNN, RMSSD, NN50, HF (ms), HF (nu), SD1, SD2, and higher LF (ms), LF (nu), LF/HF, SD1/SD2, DFA-α1, and DFA-α2, compared to normal weight. A lower and higher capacity for producing IL-10 (p= 0.039) and IL-2 (p= 0.009), respectively, were found in children with obesity compared to children with normal weight. Although IL-2, IL-4 and IL17A did not correlate with HRV parameters, IL-6 was positively correlated with SDNN, LF (ms) and SD2, TNF-α was positively correlated with LF/HF and SD1/SD2 ratio, and IFN-γ was positively correlated with SDNN, RMMSSD, NN50, LF (ms), HF (ms), SD1, and SD2. Conclusions The findings suggest that children with obesity have impaired autonomic function and systemic low-grade inflammation compared to children within the normal weight range, the inflammatory biomarkers were correlated with HRV parameters in schoolchildren living in the northeastern region of Brazil.
dc.identifier.doi10.1016/j.jped.2023.07.003
dc.identifier.issn0021-7557
dc.identifier.otherS0021-75572024000100074-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/801
dc.relation.ispartofJornal de Pediatria
dc.subjectChildren
dc.subjectObesity
dc.subjectHeart rate variability
dc.subjectCytokines
dc.titleEvaluation of cardiac autonomic function and low-grade inflammation in children with obesity living in the Northeast Brazilian region
dc.typeArtigos
oaire.citation.endPage80
oaire.citation.issue1
oaire.citation.startPage74
oaire.citation.volume100

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