Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

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dc.contributor.authorFernandes, Leandro Araújo
dc.contributor.authorMartins, Thiago Marchi
dc.contributor.authorAlmeida, Juliano Milanezi De
dc.contributor.authorNagata, Maria José Hitomi
dc.contributor.authorTheodoro, Leticia Helena
dc.contributor.authorGarcia, Valdir Gouveia
dc.contributor.authorBosco, Alvaro Francisco
dc.date.accessioned2024-05-15T20:31:22Z
dc.date.available2024-05-15T20:31:22Z
dc.date.issued2010
dc.description.abstractOBJECTIVE: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
dc.identifier.issn1678-7757
dc.identifier.otherS1678-77572010000600017-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/1402
dc.relation.ispartofJournal of Applied Oral Science
dc.subjectIrrigation
dc.subjectPeriodontal diseases
dc.subjectPeriodontitis
dc.subjectRats
dc.subjectTetracycline
dc.titleExperimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
dc.typeArtigos
oaire.citation.endPage640
oaire.citation.issue6
oaire.citation.startPage635
oaire.citation.volume18

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