Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)

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dc.contributor.authorSilva, Dayanne Meneses
dc.contributor.authorCosta, Emmanoel Vilaça
dc.contributor.authorNogueira, Paulo Cesar de Lima
dc.contributor.authorMoraes, Valéria Regina de Souza
dc.contributor.authorCavalcanti, Sócrates Cabral de Holanda
dc.contributor.authorSalvador, Marcos José
dc.contributor.authorRibeiro, Luis Henrique Gonzaga
dc.contributor.authorGadelha, Fernanda Ramos
dc.contributor.authorBarison, Andersson
dc.contributor.authorFerreira, Antonio Gilberto
dc.date.accessioned2024-05-20T16:51:10Z
dc.date.available2024-05-20T16:51:10Z
dc.date.issued2012
dc.description.abstractPhytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.
dc.identifier.issn0100-4042
dc.identifier.otherS0100-40422012000800015-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/2242
dc.relation.ispartofQuímica Nova
dc.subjectXylopia laevigata
dc.subjectent-kaurane-diterpenes
dc.subjectlarvicidal and antifungal properties
dc.titleEnt-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
dc.typeArtigos
oaire.citation.endPage1576
oaire.citation.issue8
oaire.citation.startPage1570
oaire.citation.volume35

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