Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

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dc.contributor.authorvan de Graaf, Guilherme Maia Mulder
dc.contributor.authorDe Zoppa, Andre Luis do Valle
dc.contributor.authorMoreira, Rodrigo Crispim
dc.contributor.authorMaestrelli, Sylma Carvalho
dc.contributor.authorMarques, Rodrigo Fernando Costa
dc.contributor.authorCampos, Maria Gabriela Nogueira
dc.date.accessioned2024-05-16T00:07:47Z
dc.date.available2024-05-16T00:07:47Z
dc.date.issued2015
dc.description.abstractIntroduction: Bone diseases, aging and traumas can cause bone loss and lead to bone defects. Treatment of bone defects is challenging, requiring chirurgical procedures. Bone grafts are widely used for bone replacement, but they are limited and expensive. Due to bone graft limitations, natural, semi-synthetic, synthetic and composite materials have been studied as potential bone-graft substitutes. Desirable characteristics of bone-graft substitutes are high osteoinductive and angiogenic potentials, biological safety, biodegradability, bone-like mechanical properties, and reasonable cost. Herein, we prepared and characterized potential bone-graft substitutes composed of calcium phosphate (CP) - a component of natural bone, and chitosan (CS) - a biocompatible biopolymer. Methods CP-CS composites were synthetized, molded, dried and characterized. The effect of drying temperatures (38 and 60 °C) on the morphology, porosity and chemical composition of the composites was evaluated. As well, the effects of drying temperature and period of drying (3, 24, 48 and 72 hours) on the mechanical properties - compressive strength, modulus of elasticity and relative deformation-of the demolded samples were investigated. Results Scanning electron microscopy and gas adsorption-desorption analyses of the CS-CP composites showed interconnected pores, indicating that the drying temperature played an important role on pores size and distribution. In addition, drying temperature have altered the color (brownish at 60 °C due to Maillard reaction) and the chemical composition of the samples, confirmed by FTIR. Conclusion Particularly, prolonged period of drying have improved mechanical properties of the CS-CP composites dried at 38 °C, which can be designed according to the mechanical needs of the replaceable bone.
dc.identifier.doi10.1590/2446-4740.0786
dc.identifier.issn2446-4740
dc.identifier.otherS2446-47402015000400334-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/1473
dc.relation.ispartofResearch on Biomedical Engineering
dc.subjectChitosan
dc.subjectCalcium phosphate
dc.subjectBone-grafts
dc.subjectSubstitutes
dc.subjectMechanical properties
dc.titleMorphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes
dc.typeArtigos
oaire.citation.endPage342
oaire.citation.issue4
oaire.citation.startPage334
oaire.citation.volume31

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