Sorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes

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dc.contributor.authorCampos, Maria Gabriela Nogueira
dc.contributor.authorMei, Lucia Helena Innocentini
dc.contributor.authorSantos Jr, Arnaldo Rodrigues
dc.date.accessioned2024-05-16T14:57:53Z
dc.date.available2024-05-16T14:57:53Z
dc.date.issued2015
dc.description.abstractChitosan is soluble in diluted acid solutions and can easily form films by casting. However, residual acid neutralization should be performed for biomedical applications what may compromise physical and mechanical properties of the films. Thus, plasticizers can be added to improve these properties. The aim of this study was to characterize morphological, barrier and mechanical properties, besides evaluate the in vitro cytotoxicity of sorbitol-plasticized and NaOH-Na2CO3 neutralized chitosan membranes for skin substitute application. Scanning electron microscopy, X-ray diffraction, water vapor permeability and mechanical tests were carried out to characterize the obtained membranes. Moreover, Vero cells were used for in vitro cytotoxicity evaluation. In this paper, we report a non-cytotoxic sorbitol-plasticized chitosan membrane with desirable properties for skin substitution, such as flexibility, water vapor permeability and high percentage of elongation.
dc.identifier.doi10.1590/1516-1439.025015
dc.identifier.issn1516-1439
dc.identifier.otherS1516-14392015000400781-scl
dc.identifier.urihttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/1643
dc.relation.ispartofMaterials Research
dc.subjectchitosan
dc.subjectsorbitol
dc.subjectskin substitute
dc.subjectcytotoxicity
dc.subjectVero cells
dc.titleSorbitol-Plasticized and Neutralized Chitosan Membranes as Skin Substitutes
dc.typeArtigos
oaire.citation.endPage790
oaire.citation.issue4
oaire.citation.startPage781
oaire.citation.volume18

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