Navegando por Autor "Gadelha, Fernanda Ramos"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
    (2012) Silva, Dayanne Meneses; Costa, Emmanoel Vilaça; Nogueira, Paulo Cesar de Lima; Moraes, Valéria Regina de Souza; Cavalcanti, Sócrates Cabral de Holanda; Salvador, Marcos José; Ribeiro, Luis Henrique Gonzaga; Gadelha, Fernanda Ramos; Barison, Andersson; Ferreira, Antonio Gilberto
    Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.
  • Nenhuma Miniatura disponível
    Item
    Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
    (2012) Silva, Dayanne Meneses; Costa, Emmanoel Vilaça; Nogueira, Paulo Cesar de Lima; Moraes, Valéria Regina de Souza; Cavalcanti, Sócrates Cabral de Holanda; Salvador, Marcos José; Ribeiro, Luis Henrique Gonzaga; Gadelha, Fernanda Ramos; Barison, Andersson; Ferreira, Antonio Gilberto
    Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.