Carvalho, Déborah EstevesPimentel, João Victor AndradeSilva, Luise Oliveira Ribeiro daRodrigues, Letícia Maria Cardoso LimaAndrade, Leonardo SantanaSantana, Carlos Ramon CostaMenezes, Marcelo Antônio SilvaSilva, Eloyse Emanuelle NunesSantos, Gabryelle Eduarda Gama dosSantos, Sayron Natanael Lopes PereiraGomes, Breno Gustavo do NascimentoMeira, Letícia AlmeidaSantos, Helga Machado de FariasLopes, Izailza Matos Dantas2024-05-212024-05-2120230037-8682S0037-86822023000100704-scl10.1590/0037-8682-0038-2023https://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/2383ABSTRACT Congenital and gestational syphilis are increasingly prevalent multisystemic infections in Brazil. This study aimed to present a case series of three children diagnosed with congenital syphilis even though their mother had unreactive treponemal tests. The VDRL (Venereal Disease Research Laboratory) titers of a 22-year-old mother with three pregnancies decreased after treatment. The mother did not have a reactive treponemal test, but all the three children were diagnosed with early congenital syphilis. This case series highlights the difficulty in diagnosing gestational and congenital syphilis in Brazil.Gestational syphilisTreponemal testsEarly congenital syphilisArtigos