Silva, Dayanne MenesesCosta, Emmanoel VilaçaNogueira, Paulo Cesar de LimaMoraes, Valéria Regina de SouzaCavalcanti, Sócrates Cabral de HolandaSalvador, Marcos JoséRibeiro, Luis Henrique GonzagaGadelha, Fernanda RamosBarison, AnderssonFerreira, Antonio Gilberto2024-05-202024-05-2020120100-4042S0100-40422012000800015-sclhttps://repositorio-aptaregional.agricultura.sp.gov.br/handle/123456789/2242Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.Xylopia laevigataent-kaurane-diterpeneslarvicidal and antifungal propertiesArtigos